Germline-Dependent Antibody Paratope States and Pairing Specific VH-VL Interface Dynamics

Germline-Dependent Antibody Paratope States and Pairing Specific VH-VL Interface Dynamics

Antibodies have emerged as one of the fastest growing classes of biotherapeutic proteins. To improve the rational design of antibodies, we investigate the conformational diversity of 16 different germline combinations, which are composed of 4 different kappa light chains paired with 4 different heav...

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Bibliographic Details
Main Authors: Monica L. Fernández-Quintero, Katharina B. Kroell, Lisa M. Bacher, Johannes R. Loeffler, Patrick K. Quoika, Guy Georges, Alexander Bujotzek, Hubert Kettenberger, Klaus R. Liedl
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
antibodies
germlines
VH-VL pairings
paratope states in solution
backbone vs. sidechain flexibility
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.675655/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.675655/full

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