T-2 Toxin Induces Oxidative Stress at Low Doses via Atf3ΔZip2a/2b-Mediated Ubiquitination and Degradation of Nrf2

T-2 Toxin Induces Oxidative Stress at Low Doses via Atf3ΔZip2a/2b-Mediated Ubiquitination and Degradation of Nrf2

T-2 toxin is mainly produced by <i>Fusarium</i> species, which is an extremely toxic mycotoxin to humans and animals. It is well known that T-2 toxin induces oxidative stress, but the molecular mechanism is still unknown. In this study, we found that T-2 toxin significantly promoted reac...

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Bibliographic Details
Main Authors: Xiaoxuan Chen, Peiqiang Mu, Lang Zhu, Xiaoxiao Mao, Shuang Chen, Huali Zhong, Yiqun Deng
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
T-2 toxin
ROS
ATF3ΔZip2a/2b
Nrf2
ubiquitination
degradation
Online Access:https://www.mdpi.com/1422-0067/22/15/7936

Internet

https://www.mdpi.com/1422-0067/22/15/7936

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