A systematic comparison of recurrent event models for application to composite endpoints

A systematic comparison of recurrent event models for application to composite endpoints

Abstract Background Many clinical trials focus on the comparison of the treatment effect between two or more groups concerning a rarely occurring event. In this situation, showing a relevant effect with an acceptable power requires the observation of a large number of patients over a long period of...

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Bibliographic Details
Main Authors: Ann-Kathrin Ozga, Meinhard Kieser, Geraldine Rauch
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Medical Research Methodology
Subjects:
Recurrent event analysis
Composite endpoints
Simulation study
Online Access:http://link.springer.com/article/10.1186/s12874-017-0462-x

Internet

http://link.springer.com/article/10.1186/s12874-017-0462-x

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