Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer’s disease (AD). A popular theory that seeks to explain the apparent spread of neurofibrillary tangle pathology proposes that aggregated tau is passed from neuron to neuron. Such a templated seeding process require...

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Bibliographic Details
Main Authors: Francesc X. Guix, Grant T. Corbett, Diana J. Cha, Maja Mustapic, Wen Liu, David Mengel, Zhicheng Chen, Elena Aikawa, Tracy Young-Pearse, Dimitrios Kapogiannis, Dennis J. Selkoe, Dominic M. Walsh
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
biomarkers
cerebrospinal fluid
exosomes
iPSCs
neuron
plasma
Online Access:http://www.mdpi.com/1422-0067/19/3/663

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http://www.mdpi.com/1422-0067/19/3/663

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