Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in PancreatitisSummary

Background & Aims: Mitogen-activated protein kinase (MAPK) signaling in the exocrine pancreas has been extensively studied in the context of pancreatic cancer, where its potential as a therapeutic target is limited by acquired drug resistance. However, its role in pancreatitis is less understood...

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Bibliographic Details
Main Authors: Christopher J. Halbrook, Hui-Ju Wen, Jeanine M. Ruggeri, Kenneth K. Takeuchi, Yaqing Zhang, Marina Pasca di Magliano, Howard C. Crawford
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X16301102