Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9...

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Bibliographic Details
Main Authors: David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08586-3

Internet

https://doi.org/10.1038/s41467-019-08586-3

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