Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9...

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Main Authors:	David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08586-3

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spelling	doaj-c9f52c1c744446f184d2f160044012922021-05-11T12:26:41ZengNature Publishing GroupNature Communications2041-17232019-02-0110111610.1038/s41467-019-08586-3Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancerDavid M. Gay0Rachel A. Ridgway1Miryam Müller2Michael C. Hodder3Ann Hedley4William Clark5Joshua D. Leach6Rene Jackstadt7Colin Nixon8David J. Huels9Andrew D. Campbell10Thomas G. Bird11Owen J. Sansom12Cancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteWhether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.https://doi.org/10.1038/s41467-019-08586-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	David M. Gay Rachel A. Ridgway Miryam Müller Michael C. Hodder Ann Hedley William Clark Joshua D. Leach Rene Jackstadt Colin Nixon David J. Huels Andrew D. Campbell Thomas G. Bird Owen J. Sansom
spellingShingle	David M. Gay Rachel A. Ridgway Miryam Müller Michael C. Hodder Ann Hedley William Clark Joshua D. Leach Rene Jackstadt Colin Nixon David J. Huels Andrew D. Campbell Thomas G. Bird Owen J. Sansom Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer Nature Communications
author_facet	David M. Gay Rachel A. Ridgway Miryam Müller Michael C. Hodder Ann Hedley William Clark Joshua D. Leach Rene Jackstadt Colin Nixon David J. Huels Andrew D. Campbell Thomas G. Bird Owen J. Sansom
author_sort	David M. Gay
title	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_short	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_full	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_fullStr	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_full_unstemmed	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_sort	loss of bcl9/9l suppresses wnt driven tumourigenesis in models that recapitulate human cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.
url	https://doi.org/10.1038/s41467-019-08586-3
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Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

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