Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

Abstract Spinal bulbar muscular atrophy (SBMA) is an adult-onset, slowly progressive motor neuron disease caused by abnormal CAG repeat expansion in the androgen receptor (AR) gene. Although ligand (testosterone)-dependent mutant AR aggregation has been shown to play important roles in motor neurona...

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Bibliographic Details
Main Authors: Kazunari Onodera, Daisuke Shimojo, Yasuharu Ishihara, Masato Yano, Fuyuki Miya, Haruhiko Banno, Naoko Kuzumaki, Takuji Ito, Rina Okada, Bruno de Araújo Herculano, Manabu Ohyama, Mari Yoshida, Tatsuhiko Tsunoda, Masahisa Katsuno, Manabu Doyu, Gen Sobue, Hideyuki Okano, Yohei Okada
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Molecular Brain
Subjects:
Spinal bulbar muscular atrophy
Induced pluripotent stem cells
iPSC-derived motor neurons
RNA sequencing
Gene set enrichment analysis
Synapse
Online Access:http://link.springer.com/article/10.1186/s13041-020-0561-1

Internet

http://link.springer.com/article/10.1186/s13041-020-0561-1

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