Leishmania Encodes a Bacterium-like 2,4-Dienoyl-Coenzyme A Reductase That Is Required for Fatty Acid β-Oxidation and Intracellular Parasite Survival

Leishmania Encodes a Bacterium-like 2,4-Dienoyl-Coenzyme A Reductase That Is Required for Fatty Acid β-Oxidation and Intracellular Parasite Survival

The Trypanosomatidae are protozoan parasites that infect insects, plants, and animals and have evolved complex monoxenous (single host) and dixenous (two hosts) lifestyles. A number of species of Trypanosomatidae, including Leishmania spp., have evolved the capacity to survive within intracellular n...

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Bibliographic Details
Main Authors: Geo Semini, Daniel Paape, Martin Blume, M. Fleur Sernee, Diego Peres-Alonso, Sébastien Calvignac-Spencer, Jörg Döllinger, Stefan Jehle, Eleanor Saunders, Malcolm J. McConville, Toni Aebischer
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
kinetoplastida
lateral gene transfer
mitochondrial metabolism
virulence factors
Online Access:https://doi.org/10.1128/mBio.01057-20

Internet

https://doi.org/10.1128/mBio.01057-20

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