How do alignment programs perform on sequencing data with varying qualities and from repetitive regions?

How do alignment programs perform on sequencing data with varying qualities and from repetitive regions?

<p>Abstract</p> <p>Background</p> <p>Next-generation sequencing technologies generate a significant number of short reads that are utilized to address a variety of biological questions. However, quite often, sequencing reads tend to have low quality at the 3’ end and ar...

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Bibliographic Details
Main Authors: Yu Xiaoqing, Guda Kishore, Willis Joseph, Veigl Martina, Wang Zhenghe, Markowitz Sanford, Adams Mark D, Sun Shuying
Format: Article
Language:English
Published: BMC 2012-06-01
Series:BioData Mining
Subjects:
Next generation sequencing
Alignment
Sequencing quality
SOAP2
Bowtie
BWA
Novoalign
Online Access:http://www.biodatamining.org/content/5/1/6

Internet

http://www.biodatamining.org/content/5/1/6

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