Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Dementia with Lewy bodies (DLB), Parkinson’s disease (PD) and multiple system atrophy are characterized by the deposition of disease-associated α-synuclein. In the present study we 1) examined the molecular specificity of the novel anti-α-synuclein 5G4 antibody; 2) evaluated immunoreactivity pattern...

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Bibliographic Details
Main Authors: Gabor G. Kovacs, Leonid Breydo, Ryan Green, Viktor Kis, Gina Puska, Péter Lőrincz, Laura Perju-Dumbrava, Regina Giera, Walter Pirker, Mirjam Lutz, Ingolf Lachmann, Herbert Budka, Vladimir N. Uversky, Kinga Molnár, Lajos László
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Neurobiology of Disease
Subjects:
α-synuclein
endosome
ependyma
gap junction
internalisation
lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001387

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http://www.sciencedirect.com/science/article/pii/S0969996114001387

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