A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM<sup>-</sup>/CD133<sup>-</sup> nonStem Cells into EpCAM<sup>+</sup>/CD133<sup>+</sup> Liver Cancer Stem Cells in HCC Cell Line HuH7

A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM<sup>-</sup>/CD133<sup>-</sup> nonStem Cells into EpCAM<sup>+</sup>/CD133<sup>+</sup> Liver Cancer Stem Cells in HCC Cell Line HuH7

The complex and heterogeneous nature of hepatocellular carcinoma (HCC) hampers the identification of effective therapeutic strategies. Cancer stem cells (CSCs) represent a fraction of cells within tumors with the ability to self-renew and differentiate, and thus significantly contribute to the forma...

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Bibliographic Details
Main Authors: Zeynep Firtina Karagonlar, Soheil Akbari, Mustafa Karabicici, Eren Sahin, Sanem Tercan Avci, Nevin Ersoy, Kıvılcım Eren Ates, Tugsan Balli, Bilge Karacicek, Kubra Nur Kaplan, Canan Celiker, Nese Atabey, Esra Erdal
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
hepatocellular carcinoma (HCC)
liver cancer stem cells
tumor plasticity
KLF4
reprogramming
EpCAM
Online Access:https://www.mdpi.com/2073-4409/9/5/1198

Internet

https://www.mdpi.com/2073-4409/9/5/1198

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