EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer

EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer

Forkhead Box O3 (FOXO3) is a tumor suppressor whose activity is fine-tuned by post-translational modifications (PTMs). In this study, using the BT474 breast cancer cells and a recently established lapatinib resistant (BT474-Lap<sup>R</sup>) cell line, we observed that higher FOXO3 and ac...

Full description

Bibliographic Details
Main Authors: Zimam Mahmud, Ana R. Gomes, Hee Jin Lee, Sathid Aimjongjun, Yannasittha Jiramongkol, Shang Yao, Stefania Zona, Glowi Alasiri, Gyungyub Gong, Ernesto Yagüe, Eric W.-F. Lam
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
acetylation
breast cancer
drug resistance
EP300
sirtuins
FOXO3
lapatinib
post-translational modifications
Online Access:https://www.mdpi.com/2072-6694/11/8/1067

Internet

https://www.mdpi.com/2072-6694/11/8/1067

Similar Items