T Regulatory Cells From Non-obese Diabetic Mice Show Low Responsiveness to IL-2 Stimulation and Exhibit Differential Expression of Anergy-Related and Ubiquitination Factors

T Regulatory Cells From Non-obese Diabetic Mice Show Low Responsiveness to IL-2 Stimulation and Exhibit Differential Expression of Anergy-Related and Ubiquitination Factors

Foxp3+ Regulatory T cells (Tregs) are pivotal for the maintenance of tolerance. Alterations in their number and/or function have been proposed to occur in the autoimmune-prone non-obese diabetic (NOD) mouse. Comparing the frequencies and absolute numbers of CD4+Foxp3+CD25+ Tregs among 4 to 6-week ol...

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Bibliographic Details
Main Authors: Gloria J. Godoy, Carolina Olivera, Daniela A. Paira, Florencia C. Salazar, Yamile Ana, Cinthia C. Stempin, Ruben D. Motrich, Virginia E. Rivero
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
NOD mice
regulatory T cells
IL-2 signaling
GRAIL
STUB1
USP7
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02665/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02665/full

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