PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer

PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer

Summary: Variants in the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) are associated with inflammatory disorders, including inflammatory bowel diseases, rheumatoid arthritis, and type 1 diabetes. The anti-inflammatory role of PTPN2 is highlighted by the fact that PTPN...

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Bibliographic Details
Main Authors: Marianne R. Spalinger, Roberto Manzini, Larissa Hering, Julianne B. Riggs, Claudia Gottier, Silvia Lang, Kirstin Atrott, Antonia Fettelschoss, Florian Olomski, Thomas M. Kündig, Michael Fried, Declan F. McCole, Gerhard Rogler, Michael Scharl
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
inflammasome
TC-PTP
inflammatory bowel disease
IBD
colitis
interleukin-1-alpha
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301013

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http://www.sciencedirect.com/science/article/pii/S2211124718301013

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