Role of DNA Damage Response in Suppressing Malignant Progression of Chronic Myeloid Leukemia and Polycythemia Vera: Impact of Different Oncogenes

Role of DNA Damage Response in Suppressing Malignant Progression of Chronic Myeloid Leukemia and Polycythemia Vera: Impact of Different Oncogenes

Inflammatory and oncogenic signaling, both known to challenge genome stability, are key drivers of <i>BCR-ABL</i>-positive chronic myeloid leukemia (CML) and <i>JAK2</i> V617F-positive chronic myeloproliferative neoplasms (MPNs). Despite similarities in chronic inflammation a...

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Bibliographic Details
Main Authors: Jan Stetka, Jan Gursky, Julie Liñan Velasquez, Renata Mojzikova, Pavla Vyhlidalova, Lucia Vrablova, Jiri Bartek, Vladimir Divoky
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
DNA damage response
chronic myeloid leukemia
polycythemia vera
ATM-Chk2 pathway
Online Access:https://www.mdpi.com/2072-6694/12/4/903

Internet

https://www.mdpi.com/2072-6694/12/4/903

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