PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma

While pulmonary ILC2s represent one of the major tissue-resident innate lymphoid cell populations at steady state and are key drivers of cytokine secretion in their occupational niche, their role in pulmonary cancer progression remains unclear. As the programmed cell death protein-1 (PD-1) plays a m...

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Bibliographic Details
Main Authors: Emily Howard, Benjamin P. Hurrell, Doumet Georges Helou, Christine Quach, Jacob D. Painter, Pedram Shafiei-Jahani, Marshall Fung, Parkash S. Gill, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
innate lymphoid cell 2
cancer
melanoma
PD-1
TNF - α
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.733136/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.733136/full

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