Nectin-1 Expression Correlates with the Susceptibility of Malignant Melanoma to Oncolytic Herpes Simplex Virus In Vitro and In Vivo

Nectin-1 Expression Correlates with the Susceptibility of Malignant Melanoma to Oncolytic Herpes Simplex Virus In Vitro and In Vivo

Talimogene laherparepvec (T-VEC), an oncolytic herpes simplex virus, is approved for intralesional injection of unresectable stage IIIB/IVM1a melanoma. However, it is still unclear which parameter(s) predict treatment response or failure. Our study aimed at characterizing surface receptors Nectin-1...

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Bibliographic Details
Main Authors: Barbara Schwertner, Georg Lindner, Camila Toledo Stauner, Elisa Klapproth, Clara Magnus, Anette Rohrhofer, Stefanie Gross, Beatrice Schuler-Thurner, Veronika Öttl, Nicole Feichtgruber, Konstantin Drexler, Katja Evert, Michael P. Krahn, Mark Berneburg, Barbara Schmidt, Philipp Schuster, Sebastian Haferkamp
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
malignant melanoma
oncolytic
herpes simplex virus
T-VEC
nectin-1
Online Access:https://www.mdpi.com/2072-6694/13/12/3058

Internet

https://www.mdpi.com/2072-6694/13/12/3058

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