Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia

Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia

Abstract Background Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms underlying the role of PML-RARα in leukemogenesis remain largely unknown. Results Using an inducible system, we comprehen...

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Bibliographic Details
Main Authors: Ping Wang, Zhonghui Tang, Byoungkoo Lee, Jacqueline Jufen Zhu, Liuyang Cai, Przemyslaw Szalaj, Simon Zhongyuan Tian, Meizhen Zheng, Dariusz Plewczynski, Xiaoan Ruan, Edison T. Liu, Chia-Lin Wei, Yijun Ruan
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Genome Biology
Subjects:
PML-RARα
ChIA-PET
3D genome architecture
CTCF
RNA polymerase II (RNAPII)
Transcription factor (TF)
Online Access:http://link.springer.com/article/10.1186/s13059-020-02030-2

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http://link.springer.com/article/10.1186/s13059-020-02030-2

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