Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells

Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells

Abstract Background Galectins are beta-galactose specific binding proteins. In human cancers, including hepatocellular carcinoma (HCC), galectin-1 (Gal-1) is often found to be overexpressed. In order to combat the dismal diagnosis and death rates of HCC, gene silencing and targeted inhibition of Gal...

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Bibliographic Details
Main Authors: Zoe Leung, Frankie Chi Fat Ko, Sze Keong Tey, Ernest Man Lok Kwong, Xiaowen Mao, Bonnie Hei Man Liu, Angel Po Yee Ma, Yi Man Eva Fung, Chi-Ming Che, Danny Ka Ho Wong, Ching Lung Lai, Irene Oi-Lin Ng, Judy Wai Ping Yam
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Galectin-1
Hepatocellular carcinoma
miR-22
Therapeutics
OTX008
Online Access:http://link.springer.com/article/10.1186/s13046-019-1402-x

Internet

http://link.springer.com/article/10.1186/s13046-019-1402-x

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