Soluble Calreticulin Induces Tumor Necrosis Factor-α (TNF-α) and Interleukin (IL)-6 Production by Macrophages through Mitogen-Activated Protein Kinase (MAPK) and NFκB Signaling Pathways

Soluble Calreticulin Induces Tumor Necrosis Factor-α (TNF-α) and Interleukin (IL)-6 Production by Macrophages through Mitogen-Activated Protein Kinase (MAPK) and NFκB Signaling Pathways

We have recently reported that soluble calreticulin (CRT) accumulates in the sera of patients with rheumatoid arthritis or systemic lupus erythematosus. Moreover, following self-oligomerization, soluble recombinant CRT (rCRT) polypeptides exhibit potent immunostimulatory activities including macroph...

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Bibliographic Details
Main Authors: Cui-Cui Duo, Fang-Yuan Gong, Xiao-Yan He, Yan-Mei Li, Jun Wang, Jin-Ping Zhang, Xiao-Ming Gao
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
calreticulin
macrophage
MAPK
NFκB
scavenger receptor A
Online Access:http://www.mdpi.com/1422-0067/15/2/2916

Internet

http://www.mdpi.com/1422-0067/15/2/2916

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