The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells

The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells

Background and objective: A number of studies have highlighted muscle-specific mechanisms of thermogenesis involving futile cycling of Ca2+ driven by sarco (endo)plasmic reticulum Ca2+-ATPase (SERCA) and generating heat from ATP hydrolysis to be a promising strategy to counteract obesity and metabol...

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Bibliographic Details
Main Authors: Abel M. Mengeste, Jenny Lund, Parmeshwar Katare, Roya Ghobadi, Hege G. Bakke, Per Kristian Lunde, Lars Eide, Gavin O’ Mahony, Sven Göpel, Xiao-Rong Peng, Eili Tranheim Kase, G. Hege Thoresen, Arild C. Rustan
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
Obesity
Type 2 diabetes
Skeletal muscle
SERCA
Glucose metabolism
Lipid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S259025712100047X

Internet

http://www.sciencedirect.com/science/article/pii/S259025712100047X

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