p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis

p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis

NADPH oxidase-derived reactive oxygen species (ROS) regulates platelet function and thrombosis. It remains controversial regarding NOX2’s role in platelet function. As a regulatory subunit for NOX2, whether p47phox regulates platelet function remains unclear. Our study intends to evaluate p47phox’s...

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Bibliographic Details
Main Authors: Xiamin Wang, Sixuan Zhang, Yangyang Ding, Huan Tong, Xiaoqi Xu, Guangyu Wei, Yuting Chen, Wen Ju, Chunling Fu, Kunming Qi, Zhenyu Li, Lingyu Zeng, Kailin Xu, Jianlin Qiao
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Redox Biology
Subjects:
p47phox
NOX1
NOX2
Platelet function
Thrombosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720301907

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http://www.sciencedirect.com/science/article/pii/S2213231720301907

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