Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms

Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms

We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system. Three SNPs (A116S, T400I, and A439V) exhibited reduced uptake of both [ 3H]histamine and [3H]...

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Bibliographic Details
Main Authors: Takeshi Sakata, Naohiko Anzai, Toru Kimura, Daisaku Miura, Toshiyuki Fukutomi, Michio Takeda, Hiroyuki Sakurai, Hitoshi Endou
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131930920X

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http://www.sciencedirect.com/science/article/pii/S134786131930920X

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