Detection of Urinary Exosomal HSD11B2 mRNA Expression: A Useful Novel Tool for the Diagnostic Approach of Dysfunctional 11β-HSD2-Related Hypertension

Detection of Urinary Exosomal HSD11B2 mRNA Expression: A Useful Novel Tool for the Diagnostic Approach of Dysfunctional 11β-HSD2-Related Hypertension

ObjectiveApparent mineralocorticoid excess (AME) is an autosomal recessive disorder caused by the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzyme deficiency, traditionally assessed by measuring either the urinary cortisol metabolites ratio (tetrahydrocortisol+allotetrahydrocortisol/tetrahy...

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Bibliographic Details
Main Authors: Domenica De Santis, Annalisa Castagna, Elisa Danese, Silvia Udali, Nicola Martinelli, Francesca Morandini, Mariangela Veneri, Lorenzo Bertolone, Oliviero Olivieri, Simonetta Friso, Francesca Pizzolo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Endocrinology
Subjects:
apparent mineralocorticoid excess
11β-hydroxysteroid dehydrogenase type 2
urinary cortisol metabolites ratio
urinary exosomal mRNA
Droplet Digital PCR
HSD11B2
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.681974/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.681974/full

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