Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.

BACKGROUND:Inflammation followed by fibrosis is a component of islet dysfunction in both rodent and human type 2 diabetes. Because islet inflammation may originate from endothelial cells, we assessed the expression of selected genes involved in endothelial cell activation in islets from a spontaneou...

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Main Authors: Grégory Lacraz, Marie-Hélène Giroix, Nadim Kassis, Josiane Coulaud, Anne Galinier, Christophe Noll, Mélanie Cornut, Fabien Schmidlin, Jean-Louis Paul, Nathalie Janel, Jean-Claude Irminger, Micheline Kergoat, Bernard Portha, Marc Y Donath, Jan A Ehses, Françoise Homo-Delarche
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2737103?pdf=render

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http://europepmc.org/articles/PMC2737103?pdf=render

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