Long-Term Suppressive cART Is Not Sufficient to Restore Intestinal Permeability and Gut Microbiota Compositional Changes

Long-Term Suppressive cART Is Not Sufficient to Restore Intestinal Permeability and Gut Microbiota Compositional Changes

Background: We explored the long-term effects of cART on markers of gut damage, microbial translocation, and paired gut/blood microbiota composition, with a focus on the role exerted by different drug classes.Methods: We enrolled 41 cART naïve HIV-infected subjects, undergoing blood and fecal sampli...

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Bibliographic Details
Main Authors: Giuseppe Ancona, Esther Merlini, Camilla Tincati, Alessandra Barassi, Andrea Calcagno, Matteo Augello, Valeria Bono, Francesca Bai, Elvira S. Cannizzo, Antonella d'Arminio Monforte, Giulia Marchetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
dysbiosis
cART initiation
intestinal damage
microbial translocation
gut health
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.639291/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.639291/full

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