Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program

Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program

Summary: Osteocytes, the most abundant of bone cells, differentiate while they remain buried within the bone matrix. This encasement limits their access to nutrients and likely affects their differentiation, a process that remains poorly defined. Here, we show that restriction in glucose supply prom...

Full description

Bibliographic Details
Main Authors: Cristina Sánchez-de-Diego, Natalia Artigas, Carolina Pimenta-Lopes, José Antonio Valer, Benjamin Torrejon, Pau Gama-Pérez, Josep A. Villena, Pablo M. Garcia-Roves, José Luis Rosa, Francesc Ventura
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219301129

Internet

http://www.sciencedirect.com/science/article/pii/S2589004219301129

Similar Items