cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

Summary: The Alzheimer’s disease (AD) susceptibility gene, CD2-associated protein (CD2AP), encodes an actin binding adaptor protein, but its function in the nervous system is largely unknown. Loss of the Drosophila ortholog cindr enhances neurotoxicity of human Tau, which forms neurofibrillary tangl...

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Bibliographic Details
Main Authors: Shamsideen A. Ojelade, Tom V. Lee, Nikolaos Giagtzoglou, Lei Yu, Berrak Ugur, Yarong Li, Lita Duraine, Zhongyuan Zuo, Vlad Petyuk, Philip L. De Jager, David A. Bennett, Benjamin R. Arenkiel, Hugo J. Bellen, Joshua M. Shulman
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719309386

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http://www.sciencedirect.com/science/article/pii/S2211124719309386

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