Senolytics and senostatics as adjuvant tumour therapy

Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline. In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it blocks tumour growth. However, this is frequently incomplete, and tumour cells that recover from senescence may...

Full description

Bibliographic Details
Main Authors: Susan Short, Edward Fielder, Satomi Miwa, Thomas von Zglinicki
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419300623