Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo

Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo

NHS-IL12 is an immunocytokine, a fusion protein of IL12's functional domains and a necrosis-targeting antibody, which has shown significant effects against human rhabdomyosarcoma xenografts in a humanized tumor model, including terminal growth arrest and differentiation of the tumor cells. Here...

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Bibliographic Details
Main Authors: Franziska Eckert, Ivan Jelas, Moritz Oehme, Stephan M. Huber, Katja Sonntag, Christian Welker, Stephen D. Gillies, Wolfgang Strittmatter, Daniel Zips, Rupert Handgretinger, Karin Schilbach
Format: Article
Language:English
Published: Taylor & Francis Group 2017-06-01
Series:OncoImmunology
Subjects:
differentiation
glioma
il12
immunocytokine
radiotherapy
rhabdomyosarcoma
senescence
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1323161

Internet

http://dx.doi.org/10.1080/2162402X.2017.1323161

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