Transferring knowledge of bacterial protein interaction networks to predict pathogen targeted human genes and immune signaling pathways: a case study on M. tuberculosis

Transferring knowledge of bacterial protein interaction networks to predict pathogen targeted human genes and immune signaling pathways: a case study on M. tuberculosis

Abstract Background Bacterial invasive infection and host immune response is fundamental to the understanding of pathogen pathogenesis and the discovery of effective therapeutic drugs. However, there are very few experimental studies on the signaling cross-talks between bacteria and human host to da...

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Bibliographic Details
Main Authors: Suyu Mei, Erik K. Flemington, Kun Zhang
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Genomics
Subjects:
Pathogen-host protein interaction networks
Pathogen-host coevolution
Signaling pathways
Transfer learning
l2-regularized logistic regression
Online Access:http://link.springer.com/article/10.1186/s12864-018-4873-9

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http://link.springer.com/article/10.1186/s12864-018-4873-9

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