Chimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motions.

Chimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motions.

Enzyme engineering has been facilitated by recombination of close homologues, followed by functional screening. In one such effort, chimeras of two class-A β-lactamases - TEM-1 and PSE-4 - were created according to structure-guided protein recombination and selected for their capacity to promote bac...

Full description

Bibliographic Details
Main Authors: Christopher M Clouthier, Sébastien Morin, Sophie M C Gobeil, Nicolas Doucet, Jonathan Blanchet, Elisabeth Nguyen, Stéphane M Gagné, Joelle N Pelletier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284969/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284969/pdf/?tool=EBI

Similar Items