Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines

Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines

The synthesis of ω-di-(trideuteromethyl)-trisnorsqualenic acid has been achieved from natural squalene. The synthesis features the use of a Shapiro reaction of acetone-d6 trisylhydrazone as a key step to implement the terminal isopropylidene-d6 moiety. The obtained squalenic acid-d6 has been coupled...

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Bibliographic Details
Main Authors: Eric Buchy, Branko Vukosavljevic, Maike Windbergs, Dunja Sobot, Camille Dejean, Simona Mura, Patrick Couvreur, Didier Desmaële
Format: Article
Language:English
Published: Beilstein-Institut 2016-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
deuterium labelling
nanomedicine
Raman spectroscopy
Shapiro reaction
squalene
Online Access:https://doi.org/10.3762/bjoc.12.109

Internet

https://doi.org/10.3762/bjoc.12.109

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