Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase

Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase

2-Oxoglutarate dehydrogenase (Ogdh) is an important mitochondria redox sensor that can undergo S-glutathionylation following an increase in H2O2 levels. Although S-glutathionylation is required to protect Ogdh from irreversible oxidation while simultaneously modulating its activity it remains unknow...

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Bibliographic Details
Main Authors: Ryan J. Mailloux, D. Craig Ayre, Sherri L. Christian
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Redox Biology
Subjects:
Krebs cycle
Reactive oxygen species
Redox signaling
Glutathione
2-Oxoglutarate dehydrogenase
S-glutathionylation
Glutaredoxin-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300131

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http://www.sciencedirect.com/science/article/pii/S2213231716300131

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