Angiotensin II Type 1 Receptor Blockers Reduce Urinary Angiotensinogen Excretion and the Levels of Urinary Markers of Oxidative Stress and Inflammation in Patients with Type 2 Diabetic Nephropathy

Angiotensin II Type 1 Receptor Blockers Reduce Urinary Angiotensinogen Excretion and the Levels of Urinary Markers of Oxidative Stress and Inflammation in Patients with Type 2 Diabetic Nephropathy

Objective To demonstrate that the administration of an angiotensin (Ang) II type 1 receptor (AT1R) blocker (ARB) inhibits the vicious cycle of high glucose (HG)-reactive oxygen species (ROS)-angiotensinogen (AGT)-Ang II-AT1R-ROS by suppressing ROSs and inflammation, thus ameliorating diabetic nephro...

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Bibliographic Details
Main Authors: Susumu Ogawa, Hiroyuki Kobori, Naro Ohashi, Maki Urushihara, Akira Nishiyama, Takefumi Mori, Tsuneo Ishizuka, Kazuhiro Nako, Sadayoshi Ito
Format: Article
Language:English
Published: SAGE Publishing 2009-01-01
Series:Biomarker Insights
Online Access:https://doi.org/10.4137/BMI.S2733

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https://doi.org/10.4137/BMI.S2733

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