Merqury: reference-free quality, completeness, and phasing assessment for genome assemblies

Merqury: reference-free quality, completeness, and phasing assessment for genome assemblies

Abstract Recent long-read assemblies often exceed the quality and completeness of available reference genomes, making validation challenging. Here we present Merqury, a novel tool for reference-free assembly evaluation based on efficient k-mer set operations. By comparing k-mers in a de novo assembl...

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Bibliographic Details
Main Authors: Arang Rhie, Brian P. Walenz, Sergey Koren, Adam M. Phillippy
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Genome Biology
Subjects:
Genome assembly
Assembly validation
Benchmarking
K-mers
Haplotype phasing
Trio binning
Online Access:http://link.springer.com/article/10.1186/s13059-020-02134-9

Internet

http://link.springer.com/article/10.1186/s13059-020-02134-9

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