Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target

Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target

Background Hypusination is an essential post-translational modification in eukaryotes. The two enzymes required for this modification, namely deoxyhypusine synthase (DHS) and deoxyhypusine hydrolase are also conserved. Plasmodium falciparum human malaria parasites possess genes for both hypusination...

Full description

Bibliographic Details
Main Authors: Aiyada Aroonsri, Navaporn Posayapisit, Jindaporn Kongsee, Onsiri Siripan, Danoo Vitsupakorn, Sugunya Utaida, Chairat Uthaipibull, Sumalee Kamchonwongpaisan, Philip J. Shaw
Format: Article
Language:English
Published: PeerJ Inc. 2019-04-01
Series:PeerJ
Subjects:
Hypusination
glmS riboswitch
PfDHS
Deoxyhypusine synthase
Plasmodium falciparum
PfeIF5A
Online Access:https://peerj.com/articles/6713.pdf

Internet

https://peerj.com/articles/6713.pdf

Similar Items