Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis

Bone disease: Signals from a modified gene Studies of genetic and molecular signaling processes in the bone disease osteonecrosis, when it is associated with steroid use, reveal insights into disease development and suggest new approaches for treatment. Steroid drugs increase the risk of osteonecros...

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Bibliographic Details
Main Authors: Fei Wu, Jing Jiao, Feng Liu, Yue Yang, Shanfeng Zhang, Zhenhua Fang, Zhipeng Dai, Zhibo Sun
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-019-0220-8