HIF-1α overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriers.

HIF-1α overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriers.

Recent studies have revealed that BRCA1 and BRCA2 germline mutation-related breast cancers show frequent overexpression of hypoxia inducible factor-1α (HIF-1α), the key regulator of the hypoxia response. However, the question remained whether hypoxia is a late stage bystander or a true carcinogeneti...

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Bibliographic Details
Main Authors: Petra van der Groep, Paul J van Diest, Yvonne H C M Smolders, Margreet G E M Ausems, Rob B van der Luijt, Fred H Menko, Joost Bart, Elisabeth G E de Vries, Elsken van der Wall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3568038?pdf=render

Internet

http://europepmc.org/articles/PMC3568038?pdf=render

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