Protein Binder (ProBi) as a New Class of Structurally Robust Non-Antibody Protein Scaffold for Directed Evolution

Protein Binder (ProBi) as a New Class of Structurally Robust Non-Antibody Protein Scaffold for Directed Evolution

Engineered small non-antibody protein scaffolds are a promising alternative to antibodies and are especially attractive for use in protein therapeutics and diagnostics. The advantages include smaller size and a more robust, single-domain structural framework with a defined binding surface amenable t...

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Bibliographic Details
Main Authors: Phuong Ngoc Pham, Maroš Huličiak, Lada Biedermannová, Jiří Černý, Tatsiana Charnavets, Gustavo Fuertes, Štěpán Herynek, Lucie Kolářová, Petr Kolenko, Jiří Pavlíček, Jiří Zahradník, Pavel Mikulecky, Bohdan Schneider
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Viruses
Subjects:
directed evolution
protein scaffold
protein engineering
computational saturation
ribosome display
interleukin-10
Online Access:https://www.mdpi.com/1999-4915/13/2/190

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https://www.mdpi.com/1999-4915/13/2/190

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