Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.

Methylation at C-5 (5-mdC) of CpG base pairs, the most abundant epigenetic modification of DNA, is catalyzed by 3 essential DNA methyltransferases (Dnmt1, Dnmt3a and Dnmt3b). Aberrations in DNA methylation and Dnmts are linked to different diseases including cancer. However, their role in alcoholic...

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Bibliographic Details
Main Authors: Huban Kutay, Corie Klepper, Bo Wang, Shu-hao Hsu, Jharna Datta, Lianbo Yu, Xiaoli Zhang, Sarmila Majumder, Tasneem Motiwala, Nuzhat Khan, Martha Belury, Craig McClain, Samson Jacob, Kalpana Ghoshal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3414497?pdf=render