Microbial Enzymatic Synthesis of Amikacin Analogs With Antibacterial Activity Against Multidrug-Resistant Pathogens

Microbial Enzymatic Synthesis of Amikacin Analogs With Antibacterial Activity Against Multidrug-Resistant Pathogens

With the constant emergence of multidrug-resistant gram-negative bacteria, interest in the development of new aminoglycoside (AG) antibiotics for clinical use has increased. The regioselective modification of AG scaffolds could be an efficient approach for the development of new antibiotics with imp...

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Bibliographic Details
Main Authors: Yeon Hee Ban, Myoung Chong Song, Joong Ho Jeong, Min Seok Kwun, Chang Rae Kim, Hwi So Ryu, Eunji Kim, Je Won Park, Dong Gun Lee, Yeo Joon Yoon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Microbiology
Subjects:
amikacin analogs
microbial enzymatic synthesis
multidrug-resistant pathogens
antibacterial activity
cytotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.725916/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.725916/full

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