Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation

Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation

Numerous mutations have been observed in the Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kinase (RTK) in both germline and sporadic neuroblastoma. Here, we have investigated the Y1278S mutation, observed in four patient cases, and its potential importance in the activation of the full length...

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Bibliographic Details
Main Authors: Jikui Guan, Yasuo Yamazaki, Damini Chand, Jesper R. van Dijk, Kristina Ruuth, Ruth H. Palmer, Bengt Hallberg
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Cancers
Subjects:
ALK
kinase activation
activation loop
gain-of-function
mutation analyses
Insulin receptor
NPM-ALK
oncogene
neuroblastoma
Online Access:https://www.mdpi.com/2072-6694/9/11/149

Internet

https://www.mdpi.com/2072-6694/9/11/149

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