Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function

Reyes et al. identified and characterized dominant mutations in the MutL homolog MLH2 (in S. cerevisiae) and PMS1 (in humans) causing an increased mutator phenotype. Based on their findings, they propose that Mlh2/hPMS1-Mlh1 mutant complexes can act as roadblocks on DNA preventing mismatch repair fu...

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Bibliographic Details
Main Authors: Gloria X. Reyes, Boyu Zhao, Tobias T. Schmidt, Kerstin Gries, Matthias Kloor, Hans Hombauer
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01481-4

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https://doi.org/10.1038/s42003-020-01481-4

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