Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis

Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis

Summary: The mechanisms that govern proteolytic maturation or complete destruction of the precursor proteins p100 and p105 are fundamental to homeostasis and activation of NF-κB; however, they remain poorly understood. Using mass-spectrometry-based quantitative analysis of noncanonical LTβR-induced...

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Bibliographic Details
Main Authors: Zekiye Buket Yılmaz, Bente Kofahl, Patrick Beaudette, Katharina Baum, Inbal Ipenberg, Falk Weih, Jana Wolf, Gunnar Dittmar, Claus Scheidereit
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009681

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http://www.sciencedirect.com/science/article/pii/S2211124714009681

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