Rebeccamycin Attenuates TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Inhibiting Myosin Light Chain Kinase Production

Rebeccamycin Attenuates TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Inhibiting Myosin Light Chain Kinase Production

Background/Aims: Although proinflammatory cytokine–induced disruption of intestinal epithelial barrier integrity is associated with intestinal inflammatory disease, effective treatment for barrier dysfunction is lacking. Previously, we demonstrated that rebeccamycin alleviates epithelial barrier dys...

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Bibliographic Details
Main Authors: Akihiro Watari, Yuta Sakamoto, Kota Hisaie, Kazuki Iwamoto, Miho Fueta, Kiyohito Yagi, Masuo Kondoh
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Epithelial barrier
Intestinal cells
Myosin light chain kinase
TNF-α
Tight junction
Checkpoint kinase 1
Online Access:http://www.karger.com/Article/FullText/472367

Internet

http://www.karger.com/Article/FullText/472367

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