Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice.

Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice.

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by SFTS virus (SFTSV) infection. Despite a gradual increase of SFTS cases and high mortality in endemic regions, no specific viral therapy nor vaccine is available. Here, we developed a single recombinant pla...

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Bibliographic Details
Main Authors: Jun-Gu Kang, Kyeongseok Jeon, Hooncheol Choi, Yuri Kim, Hong-Il Kim, Hyo-Jin Ro, Yong Bok Seo, Jua Shin, Junho Chung, Yoon Kyung Jeon, Yang Soo Kim, Keun Hwa Lee, Nam-Hyuk Cho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0007813

Internet

https://doi.org/10.1371/journal.pntd.0007813

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