Intracranial Hemorrhage Following Oral Low-Dose Methotrexate After Multiple Toxicities Caused by High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia

Intracranial Hemorrhage Following Oral Low-Dose Methotrexate After Multiple Toxicities Caused by High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia

An 11-year-old male patient with the deletion of IKZF1 (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(BCR-ABL1) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity d...

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Bibliographic Details
Main Authors: Ning Xin, Zhou Fen, Cheng Li, Xiao Yan, Jin Runming
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
intracranial hemorrhage
methotrexate
toxicity
neurotoxicity
acute lymphoblastic leukemia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01072/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01072/full

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