Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice.

Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice.

Effective tuberculosis (TB) vaccine should target tubercle bacilli with various metabolic states and confer long-term protective immunity. In this study, we constructed a novel multi-stage TB subunit vaccine based on fusion protein ESAT6-Ag85B-MPT64(190-198)-Mtb8.4-HspX (LT69 for short) which combin...

Full description

Bibliographic Details
Main Authors: Hongxia Niu, Jinxiu Peng, Chunxiang Bai, Xun Liu, Lina Hu, Yanping Luo, Bingxiang Wang, Ying Zhang, Jianzhu Chen, Hongjuan Yu, Qiaoyang Xian, Bingdong Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4476732?pdf=render

Internet

http://europepmc.org/articles/PMC4476732?pdf=render

Similar Items